SIGMA IL 4 human


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Rp. 8,039,830
Katalog SLSRP3093-20UG
Brand Sigma Aldrich
Kondisi New
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Harga dan Ketersediaan

Katalog SLSRP3093-20UG
Ukuran -
Ketersedian Hubungi Kami
Harga Rp. 8,039,830
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Ulasan

IL-4 human

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested

Synonym: B cell stimulating factor (BSF-1), BCDF, BCGF

Biochem/physiol Actions

IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Recombinant human IL-4 is a 14.9 kDa globular protein containing 129 amino acid residues.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20°C to -80°C.

Physical form

Lyophilized with no additives.

General description

IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 14.9 kDa globular protein containing 129 amino acid residues.

 

Properties

Related Categories

Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cytokines & Growth Factors,Cytokines and Growth Factors,

More...

recombinant  

expressed in E. coli

assay  

≥98% (HPLC)

 

≥98% (SDS-PAGE)

form  

lyophilized

mol wt  

mol wt 14.9 kDa

impurities  

 

suitability  

cell culture tested

Swiss-Prot accession no.  

P05112

shipped in  

wet ice

storage temp.  

−20°C

Gene Information  

human ... IL4(3565)

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