SIGMA GM Colony Stimulating Factor human


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Rp. 8,039,830
Katalog SLSRP3050-20
Brand Sigma Aldrich
Kondisi New
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Harga dan Ketersediaan

Katalog SLSRP3050-20
Ukuran -
Ketersedian Hubungi Kami
Harga Rp. 8,039,830
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Ulasan

Granulocyte-Macrophage Colony-Stimulating Factor human

GM-CSF, Animal-component free, recombinant, expressed in E. coli, suitable for cell culture

Synonym: CSF-2, MGI-1GM, pluripoietin-a

 

Biochem/physiol Actions

GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. Recombinant human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20°C to -80°C.

Physical form

Lyophilized from 10 mM Sodium Citrate, pH 3.5.

General description

GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites.

 

Properties

Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors,Cytokines, Growth Factors and Chemokines for Stem Cell Differentiation
recombinant   expressed in E. coli
assay   ≥98% (SDS-PAGE)
form   lyophilized
mol wt   mol wt 14.6 kDa
impurities   ≤1 EU/μg endotoxin, tested
suitability   suitable for cell culture
Swiss-Prot accession no.   P04141
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... CSF2(1437)

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