The MAbPac HIC column family is designed for separations of monoclonal antibodies (mAbs) and related biologics by hydrophobic interaction chromatography (HIC). These columns are designed to address the separation challenges as the result of heterogeneity, complexity and diversity of mAbs and related biologics.
• Advanced column chemistry designed for separating mAbs and related biologics
• Broad selectivity coverage for most challenging separations of mAbs
• Excellent bio-compatibility
• High column efficiency
• Rugged column packing
The MAbPac HIC-10 is the column of choice for intact mAbs/proteins and mAb aggregates while the MAbPac HIC-20 is suited to resolve mAb fragments, oxidized mAbs and bispecific mAbs. When it comes to ADCs, MAbPac HIC-Butyl is ideal for cystein-conjugated ADC while MAbPac HIC-10 and MAbPac HIC-20 have proven useful for several cysteine proprietary ADC molecules, as shown below.