Metformin hydrochloride

pharmaceutical secondary standard; traceable to USP and PhEur

Synonym: 1,1-Dimethylbiguanide hydrochloride, Metformin

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Biochem/physiol Actions

Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.

General description

Certified Fluka^® pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards

Other Notes

This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (AClass Cert AT-1467), ISO GUIDES 34:2009 (AClass Cert AR-1470).

Legal Information

FLUKA is a registered trademark of FLUKA GmbH

Properties

Related Categories	Analytical Standards, Analytical/Chromatography,Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards More...
grade	certified reference material
mp	223-226 °C(lit.)
pharmacopeia traceability	traceable to PhEur M0605000
	traceable to USP 1396309

Documents

• Bulk Quote-Order Product
• MSDS

Safety Information

Symbol	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319
Precautionary statements	P305 + P351 + P338
Hazard Codes (Europe)	Xn
Risk Statements (Europe)	22-36/38
Safety Statements (Europe)	26-36
WGK Germany	3
RTECS	DU1800000