ProPac WCX-10 and SCX-10 Weak and strong cation exchange columns with exceptionally high resolution and efficiency for separations of protein variants
• Characterization and quality control assessment of monoclonal antibodies and other proteins
• Exceptionally high-resolution and high-efficiency separations
• Useful for characterization of related protein variants including deamidation and mAb lysine truncation variants
• ProPac WCX-10 contains carboxylate functional groups and ProPac SCX-10 contains sulfonate functional groups
ProPac WCX-10 and SCX-10 columns are non-porous particles that can resolve isoforms that differ by a single charged residue. A hydrophilic layer prevents unwanted secondary interactions, and a grafted cation exchange surface provides pH-based selectivity control and fast mass transfer for high-efficiency separation and moderate capacity.